![]() No trial investigated ivermectin to prevent SARS-CoV-2 infection. The trials used different doses of ivermectin and different durations of treatment. Together with four new trials, we included 11 trials with 3409 participants that investigated ivermectin combined with any usual care compared to the same usual care or placebo.įor treatment, there were five trials of people in hospital with moderate COVID-19 and six trials of outpatients with mild COVID-19. We excluded seven of the 14 trials included in the previous review as these trials did not fulfil the expected ethical and scientific criteria. We compared and summarized the results of the trials and rated our confidence in the evidence, based on common criteria such as trial methods and sizes. In this update, we also investigated the trustworthiness of the trials and only included them if they fulfilled clear ethical and scientific criteria. People treated in hospital or as outpatients had to have laboratory-confirmed COVID-19. We searched for randomized controlled trials that investigated ivermectin to prevent or treat COVID-19. – serious and non-serious unwanted effects įor prevention, we sought the effect on preventing SARS-CoV-2 infection and COVID-19 disease. – whether people's COVID-19 got better or worse We evaluated the effects of ivermectin in infected people on: We excluded trials comparing ivermectin to other medicines that do not work, like hydroxychloroquine, or whose effectiveness against COVID-19 is uncertain. We included trials comparing the medicine to placebo (dummy treatment), usual care, or treatments for COVID-19 that are known to work to some extent, such as dexamethasone. We wanted to update our knowledge of whether ivermectin reduces death, illness, and length of infection in people with COVID-19, or is useful in prevention of the infection. Medical regulators have not approved ivermectin for COVID-19. Ivermectin is a medicine used to treat parasites, such as intestinal parasites in animals, and scabies in humans. It is inexpensive and is widely used in regions of the world where parasitic infestations are common. The evidence base improved slightly in this update, but is still limited.Įvaluation of ivermectin is continuing in 31 ongoing trials, and we will update this review again when their results become available. We found no evidence to support the use of ivermectin for treating COVID-19 or preventing SARS-CoV-2 infection.
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